#Reactivity definition trial#A novel malaria elimination strategy based on reactive treatment was recently evaluated by a cluster randomized trial in a low transmission setting in The Gambia. A lack of unanimity regarding the spatial range of the intervention unit calls for greater importance to be placed on social context in conceptualizing the appropriate unit. To decrease transmission in such cases, reactive interventions target household members of clinical malaria cases, with the intervention unit (e.g., the “household/s”) derived from an epidemiological and operational perspective. With significant declines in malaria, infections are increasingly clustered in households, or groups of households where malaria transmission is higher than in surrounding household/villages. 8School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.7School of Health and Related Research (ScHARR), The University of Sheffield, Sheffield, United Kingdom.6London School of Hygiene and Tropical Medicine, London, United Kingdom.5Liverpool School of Tropical Medicine, Liverpool, United Kingdom.3Faculty of Social and Behavioural Sciences, Amsterdam Institute of Social Science Research, Amsterdam, Netherlands.2Medical Anthropology Unit, Institute of Tropical Medicine, Antwerp, Belgium.1Medical Research Council Unit the Gambia at the London School of Hygiene and Tropical Medicine, Banjul, Gambia.Fatou Jaiteh 1,2,3 *, Joan Muela Ribera 4, Yoriko Masunaga 2,3, Joseph Okebe 1,5, Umberto D'Alessandro 1,6, Julie Balen 7, Jane Achan 1,5, Rene Gerrets 3 and Koen Peeters Grietens 2,4,8
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